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How C the Signs Integrates with EMIS and SystmOne to Save Lives
C the Signs
In primary care, time matters. Every consultation, every click, and every decision can shape a patient’s outcome - especially when it comes to cancer.
That’s why C the Signs has been designed to integrate seamlessly with EMIS and SystmOne, enabling GPs to detect cancer earlier without adding extra steps to their daily workflow.
Integration That Fits Naturally Into Primary Care
For most GPs, EMIS and SystmOne are the backbone of daily practice - holding every patient’s medical history, symptoms, and risk factors. C the Signs connects directly into these systems, transforming that information into real-time, actionable insight.
Through this integration, clinicians can:
- Instantly access C the Signs from within EMIS or SystmOne
- Automatically analyse patient symptoms, demographics, and clinical data
- Receive immediate, evidence-based guidance on cancer risk and next steps
No extra software. No switching screens. No duplicate data entry. Just faster, smarter decision-making - at the point of care.
Reducing the Time to Diagnosis
C the Signs is built to make early diagnosis simple, safe, and scalable. By embedding directly into the GP’s existing system, it eliminates delays that often occur when technology sits outside the electronic medical record.
This seamless workflow means:
- Referrals can be generated instantly, including under the Faster Diagnosis Standard (FDS), formerly known as the two-week wait (2WW).
- Patient data flows automatically, avoiding missed information or transcription errors.
- Audit trails and outcomes are logged for research, safety, and quality improvement.
In practices where C the Signs is live, clinicians are already finding cancer faster and more accurately - with earlier referrals, improved outcomes, and a reduced administrative burden.
Driving Early Diagnosis Across the NHS
C the Signs integrates directly with:
- EMIS Web - used by around 70% of GP practices in England
- SystmOne - supporting thousands of GP practices, community services, and hospitals
Together, these integrations make the platform available to millions of patients across the NHS — turning data into action and ensuring that every GP, regardless of location, has access to the same level of intelligent support.
Seamless, Safe, and Clinically Validated
Every integration is developed and maintained in line with:
- NHS Digital standards
- Clinical Safety DCB0129/0160 accreditation
- Information Governance and GDPR compliance
This ensures that C the Signs operates to the highest standards of clinical safety, patient privacy, and system performance — delivering technology clinicians can trust.
Real Impact, Real Patients
“The ability to use C the Signs directly in EMIS has completely changed how quickly I can act.
I can review a patient’s symptoms, get the cancer risk assessment instantly, and make the referral — all in one place.”
— GP, South East England
Every integration helps remove barriers between data and diagnosis - giving clinicians back time and patients back their best chance of survival.
About C the Signs
C the Signs is an AI-powered clinical platform that helps healthcare professionals identify patients at risk of cancer earlier, faster, and more accurately.
Founded by NHS doctors, the platform analyses over 100 cancer types using evidence-based algorithms and integrates directly into GP workflows through EMIS, SystmOne, and Vision.
By embedding early detection tools into everyday care, C the Signs is helping achieve the NHS’s ambition:
75% of cancers diagnosed at stage 1 or 2 by 2028.
How Does C the Signs Work?
Every minute counts when it comes to cancer.
For most patients, early detection means faster treatment, better outcomes, and more lives saved.
Yet for GPs, recognising which of the thousands of daily symptoms could indicate cancer isn’t simple. That’s where C the Signs comes in - an AI-powered clinical platform that helps healthcare professionals identify patients at risk of cancer earlier, faster, and more accurately.
The Challenge: Spotting the Earliest Signs of Cancer
Cancer rarely looks the same twice. Two patients with the same disease can present in completely different ways - fatigue in one, back pain in another.
With over 100 cancer types and countless symptom combinations, even the most experienced GP can face uncertainty.
Traditional guidelines can be fragmented or difficult to navigate in a busy primary care setting.
C the Signs bridges that gap - bringing together national guidance, clinical research, and local pathways into one intelligent platform that supports decision-making in real time.
The Solution: AI-Driven Clinical Support
C the Signs analyses patient data, demographics, risk factors, and symptoms to calculate the probability of cancer - then guides the GP to the right next step.
It doesn’t replace clinical judgement.
It enhances it.
Here’s how it works in real time:
- Input – The GP enters symptoms, risk factors, or test results directly within EMIS, SystmOne, or Vision.
- Analyse – The platform’s AI interprets this data using national guidelines, research evidence, and validated clinical pathways.
- Act – Within seconds, C the Signs provides a clear recommendation - suggesting the most appropriate referral, investigation, or next action, tailored to each individual patient.
Everything happens seamlessly, within the GP’s existing workflow - saving valuable time and ensuring no symptom is overlooked.
Built on Evidence, Backed by Research
C the Signs doesn’t guess - it’s grounded in science.
Our algorithms are validated against national cancer guidelines and peer-reviewed research, and informed by real-world data from NHS England partners, Cancer Alliances, and Health Innovation Networks.
Every insight is continually refined through clinical feedback and new evidence, ensuring the platform remains aligned with the most up-to-date pathways in early diagnosis.
Seamless Integration with NHS Systems
Time is one of the most valuable resources in primary care.
That’s why C the Signs integrates directly with EMIS, SystmOne, and Vision, requiring no extra logins or manual data entry.
The platform works where GPs already work, making early detection faster, simpler, and more efficient.
Improving Early Detection Across the NHS
C the Signs is now used by over 10,000 healthcare professionals across 1,500 GP practices, supporting early cancer detection nationwide.
Independent evaluations and NHS-led studies have shown that practices using C the Signs achieve:
- Higher rates of two-week-wait referrals
- Faster time to diagnosis (a 21% reduction in diagnostic delays)
- More cancers diagnosed in primary care
- Fewer emergency presentations
By identifying patients earlier, C the Signs is helping the NHS move closer to its 2028 ambition - diagnosing 75% of cancers at stage 1 or 2.
Supporting Clinicians. Empowering Patients.
C the Signs is more than a platform - it’s a partner in early diagnosis.
By giving clinicians the confidence to act on subtle patterns and helping patients reach testing sooner, we’re redefining what’s possible in cancer care.
“Every early diagnosis is a life changed - and that’s what drives us.”
.webp)
Defying Time: How C the Signs Is Transforming Early Cancer Detection Across the NHS
At C the Signs, we believe no one should face a late cancer diagnosis.Our mission is clear and urgent - to empower every GP to detect cancer earlier and give every patient the best chance of survival.
Why We Started
Every two minutes, someone in the UK is diagnosed with cancer. For too many, it’s discovered too late - when options are fewer, outcomes are poorer, and lives are changed forever.
The challenge isn’t a lack of care or compassion - it’s the complexity of cancer itself. With over 100 cancer types and countless symptom combinations, even the most experienced GP can face uncertainty during those vital early consultations.
C the Signs was born from a single question:
“What if technology could help doctors spot the earliest signs of cancer - before it’s too late?”
That question became our why - and our purpose.
What We Do
C the Signs is an AI-powered clinical platform that helps healthcare professionals identify patients at risk of cancer - earlier, faster, and more accurately.
Our technology integrates directly with NHS electronic medical record systems like EMIS, SystmOne, and Vision, analysing combinations of:
- Signs and symptoms
- Risk factors and clinical markers
- Demographic and lifestyle data
Using validated algorithms and national evidence-based pathways, C the Signs supports GPs to assess cancer risk and identify the most appropriate referral or diagnostic route - in under 30 seconds.
The result: fewer missed cases, faster investigations, and more lives given back time.
How It Works
C the Signs combines artificial intelligence, clinical research, and national guidelines to transform medical decision-making.
- Analyse – The platform reviews real-time patient data and symptom inputs.
- Assess – AI cross-checks patterns against validated cancer pathways and the latest clinical evidence.
- Act – GPs receive instant, tailored guidance on next steps - from urgent referrals to diagnostic tests.
By translating complex data into clear, actionable insights, C the Signs enables clinicians to make faster, more confident decisions - while maintaining full clinical autonomy.
Our Impact So Far
C the Signs is now used across the UK by over 10,000 healthcare professionals in 1,500 GP practices, helping identify patients with cancer every 22 minutes.
Validated through independent evaluations and peer-reviewed studies, the platform has shown:
- 99% sensitivity for identifying patients with cancer
- 99% negative predictive value, safely ruling out risk
- 94% accuracy in predicting tumour origin
- Stage shift in harder-to-detect cancers such as pancreatic and ovarian
- Faster time to diagnosis, reducing delays by over 20%
- More equitable detection, with fewer emergency presentations and earlier referrals across diverse populations
Every earlier diagnosis represents more time - and more life - for patients and their families.
The Team Behind the Mission
C the Signs was founded by Dr Bea Bakshi and Dr Miles Payling, two NHS doctors who saw firsthand how late diagnosis can cost lives.
Their experience on the frontline of care inspired a bold vision: a future where technology and medicine work together to make early cancer detection the norm — not the exception.
Today, our multidisciplinary team of clinicians, data scientists, and innovators share one purpose:
to end late cancer diagnosis, for good.
A Future Without Late Diagnosis
Our journey is just beginning.
We’re continuing to advance our AI, expanding across care settings - from primary to secondary care and beyond - to make early cancer detection universal and equitable.
Through partnerships with Cancer Alliances, Health Innovation Networks, and NHS England, we’re shaping a future where no symptom is overlooked and no patient waits too long to be seen.
Our vision is bold, but achievable:
A world where no patient is diagnosed too late.
Join Us
Whether you’re a GP, policymaker, or innovation partner - together, we can rewrite the story of cancer care.
👉 Learn more about our research and impact.
👉 Request a demo to see how C the Signs integrates with your NHS system.
👉 Join our mission to make early detection a standard for all.
Featured
Cancer in Numbers: Why Interception Matters with Dr Miles Payling
Dr. Miles Payling
At the inaugural C the Signs Conference, Dr Miles Payling - Co-Founder and Chief Scientific Officer - delivered a message that captured the spirit of the movement redefining how the world detects cancer.
In a talk that fused science with humanity, he spoke not only about technology, but about time and how every second counts in the journey to early diagnosis.
“We can’t afford to wait for symptoms to become obvious. Every moment matters - because every moment lost is a choice, a treatment, a life that could have been saved.”
The Why - Where It All Began
Miles began with the story that shaped C the Signs’ mission. As an NHS doctor, he met a patient named Joe - fit, active, and 60 years old. After several GP visits with vague symptoms, Joe arrived at A&E jaundiced and weak. Scans confirmed metastatic pancreatic cancer. Three weeks later, Joe died.
“Joe never asked, why do I have cancer? What he asked was, why was my cancer picked up so late?”
That single question became the foundation of C the Signs - a platform designed to detect cancer early enough to change the outcome .
Today, that vision saves time and lives - with a patient with cancer detected every 22 minutes.
Why Early Detection Still Fails Too Many
Cancer remains the leading cause of death in the UK, with survival determined by the stage at diagnosis.
For breast cancer, five-year survival is 97.9 % at stage 1 but just 26.2 % at stage 4.
For bowel cancer, it falls from 91.7 % to 10.3 % .
Yet only 58.7 % of patients are diagnosed at early stages .
In primary care - where 90 % of all NHS patient contact takes place - GPs face impossible pressures: 10-minute consultations, thousands of patients, and on average just eight new cancer diagnoses a year .
“The problem isn’t people. It’s knowledge. We need to give every GP the power of precision - instantly.”
The Innovation - Redefining What’s Possible
C the Signs is an AI-powered, pan-cancer platform integrated directly with electronic health records. In under 30 seconds, it assesses risk, predicts tumour origin, and guides clinicians to the right diagnostic pathway across 100+ cancer types.
Real-world evaluations across the NHS have shown:
- 99 % sensitivity - finding nearly all patients with cancer
- 99 % negative predictive value - safely ruling out risk
- 94 % accuracy in predicting tumour origin
- 50 % reduction in emergency cancer presentations
- 21 % faster time-to-diagnosis - from 85 days to 67 days
Each figure represents a human life identified earlier, a family spared uncertainty, and a system made stronger.
The Movement - Honouring Jess’s Rule
Miles closed his speech by reflecting on Jessica Brady’s story - a 27-year-old whose symptoms were missed, leading to a late diagnosis and preventable loss .
To honour her legacy, C the Signs is implementing “Jess’s Rule” - a feature that automatically alerts clinicians when a patient presents three times or more with unresolved symptoms, and triggers a cancer risk assessment .
“We can turn tragedy into transformation - by ensuring that no patient is ever overlooked again.”
Together, we can make early cancer detection a standard for all, not a privilege for some - and give every person the time they deserve.
Innovation
How C the Signs Integrates with EMIS and SystmOne to Save Lives
In primary care, time matters. Every consultation, every click, and every decision can shape a patient’s outcome - especially when it comes to cancer.
That’s why C the Signs has been designed to integrate seamlessly with EMIS and SystmOne, enabling GPs to detect cancer earlier without adding extra steps to their daily workflow.
Integration That Fits Naturally Into Primary Care
For most GPs, EMIS and SystmOne are the backbone of daily practice - holding every patient’s medical history, symptoms, and risk factors. C the Signs connects directly into these systems, transforming that information into real-time, actionable insight.
Through this integration, clinicians can:
- Instantly access C the Signs from within EMIS or SystmOne
- Automatically analyse patient symptoms, demographics, and clinical data
- Receive immediate, evidence-based guidance on cancer risk and next steps
No extra software. No switching screens. No duplicate data entry. Just faster, smarter decision-making - at the point of care.
Reducing the Time to Diagnosis
C the Signs is built to make early diagnosis simple, safe, and scalable. By embedding directly into the GP’s existing system, it eliminates delays that often occur when technology sits outside the electronic medical record.
This seamless workflow means:
- Referrals can be generated instantly, including under the Faster Diagnosis Standard (FDS), formerly known as the two-week wait (2WW).
- Patient data flows automatically, avoiding missed information or transcription errors.
- Audit trails and outcomes are logged for research, safety, and quality improvement.
In practices where C the Signs is live, clinicians are already finding cancer faster and more accurately - with earlier referrals, improved outcomes, and a reduced administrative burden.
Driving Early Diagnosis Across the NHS
C the Signs integrates directly with:
- EMIS Web - used by around 70% of GP practices in England
- SystmOne - supporting thousands of GP practices, community services, and hospitals
Together, these integrations make the platform available to millions of patients across the NHS — turning data into action and ensuring that every GP, regardless of location, has access to the same level of intelligent support.
Seamless, Safe, and Clinically Validated
Every integration is developed and maintained in line with:
- NHS Digital standards
- Clinical Safety DCB0129/0160 accreditation
- Information Governance and GDPR compliance
This ensures that C the Signs operates to the highest standards of clinical safety, patient privacy, and system performance — delivering technology clinicians can trust.
Real Impact, Real Patients
“The ability to use C the Signs directly in EMIS has completely changed how quickly I can act.
I can review a patient’s symptoms, get the cancer risk assessment instantly, and make the referral — all in one place.”
— GP, South East England
Every integration helps remove barriers between data and diagnosis - giving clinicians back time and patients back their best chance of survival.
About C the Signs
C the Signs is an AI-powered clinical platform that helps healthcare professionals identify patients at risk of cancer earlier, faster, and more accurately.
Founded by NHS doctors, the platform analyses over 100 cancer types using evidence-based algorithms and integrates directly into GP workflows through EMIS, SystmOne, and Vision.
By embedding early detection tools into everyday care, C the Signs is helping achieve the NHS’s ambition:
75% of cancers diagnosed at stage 1 or 2 by 2028.
How Does C the Signs Work?
Every minute counts when it comes to cancer.
For most patients, early detection means faster treatment, better outcomes, and more lives saved.
Yet for GPs, recognising which of the thousands of daily symptoms could indicate cancer isn’t simple. That’s where C the Signs comes in - an AI-powered clinical platform that helps healthcare professionals identify patients at risk of cancer earlier, faster, and more accurately.
The Challenge: Spotting the Earliest Signs of Cancer
Cancer rarely looks the same twice. Two patients with the same disease can present in completely different ways - fatigue in one, back pain in another.
With over 100 cancer types and countless symptom combinations, even the most experienced GP can face uncertainty.
Traditional guidelines can be fragmented or difficult to navigate in a busy primary care setting.
C the Signs bridges that gap - bringing together national guidance, clinical research, and local pathways into one intelligent platform that supports decision-making in real time.
The Solution: AI-Driven Clinical Support
C the Signs analyses patient data, demographics, risk factors, and symptoms to calculate the probability of cancer - then guides the GP to the right next step.
It doesn’t replace clinical judgement.
It enhances it.
Here’s how it works in real time:
- Input – The GP enters symptoms, risk factors, or test results directly within EMIS, SystmOne, or Vision.
- Analyse – The platform’s AI interprets this data using national guidelines, research evidence, and validated clinical pathways.
- Act – Within seconds, C the Signs provides a clear recommendation - suggesting the most appropriate referral, investigation, or next action, tailored to each individual patient.
Everything happens seamlessly, within the GP’s existing workflow - saving valuable time and ensuring no symptom is overlooked.
Built on Evidence, Backed by Research
C the Signs doesn’t guess - it’s grounded in science.
Our algorithms are validated against national cancer guidelines and peer-reviewed research, and informed by real-world data from NHS England partners, Cancer Alliances, and Health Innovation Networks.
Every insight is continually refined through clinical feedback and new evidence, ensuring the platform remains aligned with the most up-to-date pathways in early diagnosis.
Seamless Integration with NHS Systems
Time is one of the most valuable resources in primary care.
That’s why C the Signs integrates directly with EMIS, SystmOne, and Vision, requiring no extra logins or manual data entry.
The platform works where GPs already work, making early detection faster, simpler, and more efficient.
Improving Early Detection Across the NHS
C the Signs is now used by over 10,000 healthcare professionals across 1,500 GP practices, supporting early cancer detection nationwide.
Independent evaluations and NHS-led studies have shown that practices using C the Signs achieve:
- Higher rates of two-week-wait referrals
- Faster time to diagnosis (a 21% reduction in diagnostic delays)
- More cancers diagnosed in primary care
- Fewer emergency presentations
By identifying patients earlier, C the Signs is helping the NHS move closer to its 2028 ambition - diagnosing 75% of cancers at stage 1 or 2.
Supporting Clinicians. Empowering Patients.
C the Signs is more than a platform - it’s a partner in early diagnosis.
By giving clinicians the confidence to act on subtle patterns and helping patients reach testing sooner, we’re redefining what’s possible in cancer care.
“Every early diagnosis is a life changed - and that’s what drives us.”
Defying Time: How C the Signs Is Transforming Early Cancer Detection Across the NHS
At C the Signs, we believe no one should face a late cancer diagnosis.Our mission is clear and urgent - to empower every GP to detect cancer earlier and give every patient the best chance of survival.
Why We Started
Every two minutes, someone in the UK is diagnosed with cancer. For too many, it’s discovered too late - when options are fewer, outcomes are poorer, and lives are changed forever.
The challenge isn’t a lack of care or compassion - it’s the complexity of cancer itself. With over 100 cancer types and countless symptom combinations, even the most experienced GP can face uncertainty during those vital early consultations.
C the Signs was born from a single question:
“What if technology could help doctors spot the earliest signs of cancer - before it’s too late?”
That question became our why - and our purpose.
What We Do
C the Signs is an AI-powered clinical platform that helps healthcare professionals identify patients at risk of cancer - earlier, faster, and more accurately.
Our technology integrates directly with NHS electronic medical record systems like EMIS, SystmOne, and Vision, analysing combinations of:
- Signs and symptoms
- Risk factors and clinical markers
- Demographic and lifestyle data
Using validated algorithms and national evidence-based pathways, C the Signs supports GPs to assess cancer risk and identify the most appropriate referral or diagnostic route - in under 30 seconds.
The result: fewer missed cases, faster investigations, and more lives given back time.
How It Works
C the Signs combines artificial intelligence, clinical research, and national guidelines to transform medical decision-making.
- Analyse – The platform reviews real-time patient data and symptom inputs.
- Assess – AI cross-checks patterns against validated cancer pathways and the latest clinical evidence.
- Act – GPs receive instant, tailored guidance on next steps - from urgent referrals to diagnostic tests.
By translating complex data into clear, actionable insights, C the Signs enables clinicians to make faster, more confident decisions - while maintaining full clinical autonomy.
Our Impact So Far
C the Signs is now used across the UK by over 10,000 healthcare professionals in 1,500 GP practices, helping identify patients with cancer every 22 minutes.
Validated through independent evaluations and peer-reviewed studies, the platform has shown:
- 99% sensitivity for identifying patients with cancer
- 99% negative predictive value, safely ruling out risk
- 94% accuracy in predicting tumour origin
- Stage shift in harder-to-detect cancers such as pancreatic and ovarian
- Faster time to diagnosis, reducing delays by over 20%
- More equitable detection, with fewer emergency presentations and earlier referrals across diverse populations
Every earlier diagnosis represents more time - and more life - for patients and their families.
The Team Behind the Mission
C the Signs was founded by Dr Bea Bakshi and Dr Miles Payling, two NHS doctors who saw firsthand how late diagnosis can cost lives.
Their experience on the frontline of care inspired a bold vision: a future where technology and medicine work together to make early cancer detection the norm — not the exception.
Today, our multidisciplinary team of clinicians, data scientists, and innovators share one purpose:
to end late cancer diagnosis, for good.
A Future Without Late Diagnosis
Our journey is just beginning.
We’re continuing to advance our AI, expanding across care settings - from primary to secondary care and beyond - to make early cancer detection universal and equitable.
Through partnerships with Cancer Alliances, Health Innovation Networks, and NHS England, we’re shaping a future where no symptom is overlooked and no patient waits too long to be seen.
Our vision is bold, but achievable:
A world where no patient is diagnosed too late.
Join Us
Whether you’re a GP, policymaker, or innovation partner - together, we can rewrite the story of cancer care.
👉 Learn more about our research and impact.
👉 Request a demo to see how C the Signs integrates with your NHS system.
👉 Join our mission to make early detection a standard for all.